Endocrine Abstracts

Objective: To assess glucose metabolism (GM) parameters before and after vitamin D treatment in pre-diabetic women.Material and Methods: In the study were included fifty eight women with prediabetes (impaired fasting glucose (IFG) or impaired glucose tolerance (IGT)) aged from 40 to 55 with signed informed consent. The study didn’t include women with diseases affecting the vitamin D metabolism, as well as women receiving regular vitamin D supplemen...

Background: In acromegaly, few in vivo data exist on changes of the brain parenchyma as a pathology caused by systemically elevated levels of GH and IGF-1. This is in contrast to neuropsychiatric symptoms such as depression, cognitive impairment, personality changes and pain syndromes that accompany the condition. We aimed at measuring brain tissue volumes and white matter pathology in acromegaly.Methods: Forty-three patients (age 54±14 years...

The concept of gender identity is uniquely human. Hence we are left with the phenomenon of men and women suffering from Gender Dysphoria (GD) also known as transsexualism to study the origins of gender identity in humans. It has been hypothesized that atypical levels of sex steroids during a perinatal critical period of neuronal sexual differentiation may be involved in the development of GD. In order to test this hypothesis, we investigated brain structure and function in ind...

Background: Nutrition of the children and young people with type 1 diabetes mellitus is considered a major aspect of glycaemic control and it represents a big challenge in their management. Among the different perspectives of nutritive interventions for diabetic children, there has been a debate over the recommendation of low glycaemic index diet for them. There has been debate over the efficacy of Low GI foods on diabetic patients blood glucose control. Nevertheless, Evidence...

Neuromedin B (NB) is a peptide highly expressed in adipose tissue (AT) but its function remains unclear. We showed that NB receptor (NB) knockout mice (NBR-KO) are resistant to diet-induced obesity compared to wild type (WT) and now we aimed to analyze NBR influence in adipocytes. Mesenchimal cells from perigonadal AT of WT and NBR-KO mice were isolated and maintained in growth medium (GM) as control group or in differentiation medium (DM) as induced group. After 2 weeks cells...

Objectives: GH plays a crucial role in the regulation of metabolism of human cells. Nevertheless, a direct influence of this hormone on the proliferation, maturation and differentiation of human early hematopoietic stem/progenitor cells (HSPCs) has not been investigated thoroughly. Moreover, certain deviations of hematological parameters, such as anemia or leucopenia, are commonly observed in patients with growth hormone deficiency (GHD) syndrome, which might be substantially ...

Background: Little is known about the possible deleterious effects of phthalate exposure on endogenous sex steroid levels in childrenDesign: A longitudinal study.Materials and methods: 168 Healthy children (84 girls) were examined every 6 months for 5 years, with pubertal staging, measurements of serum levels of DHEAS and Δ4-androstenedione (Adione) and repetitive longitudinal morning urinary measurements of 14 phthalate metab...

Introduction: The current epidemic of Type 2 Diabetes Mellitus (T2DM) and obesity is positively correlated with a rise in consumption of high-fructose syrups and refined carbohydrates. Recent reports have showed that feeding rodent a high-fructose diet leads to insulin resistance, glucose intolerance and dyslipidaemia. Nevertheless, its mitochondrial effects has not been fully studied yet.Aim: We decided to explore the alterations in mitochondrial bioene...

Introduction: Thiazolidinediones (TZDs) are synthetic insulin-sensitizing drugs used in the treatment of type 2 diabetes. They work as agonists of peroxisome proliferator-activated receptor γ (PPARg). TZDs action via PPARg does not exclude independent PPARg-activation effects. Our research group has recently reported that TZDs also execute direct effects implicated in glucose homeostasis. However, its mitochondrial action PPARg-independent has not been fully studied yet.<...

The influence of the hypothyroidism (H) on the glucose metabolism (GM) has not been studied by modern methods till now. We described the changes in the effect of insulin on GM in patients in artificial H and after the thyroid hormone therapy (T).Materials and Methods: We have investigated 15 female patients (age 32.8 plus/minus 8.1 years) in H (ssTSH 84.45 plus/minus 19.69 milli international units per litre; fT4 1.68 plus/minus 0.77 picomoles per litre;...